SEEK was developed to take advantage of excellent opportunities in primary healthcare to learn about children’s family environments and to facilitate help when needed. A practical approach was developed to help primary care professionals (PCPs) play this role. Two large randomized controlled trials have had very promising findings toward helping to prevent child maltreatment. SEEK helps respond to what has been learned in the Adverse Childhood Experiences (ACEs) studies: the potential long-term and substantial harm associated with childhood adversities. In addition, SEEK helps with the increasing recognition of the important need to address social determinants of health.